VEB has the new bracket up for the All-Time Sim Tournament. The 1885 Browns have the number one seed and take on the 2006 Miracle Cardinals. The 1888 Browns are in their half of the bracket, are seeded fifth, and get the 1968 Cards. I think you have to root for that series to go seven games so that we can see Bob Gibson versus Silver King in the deciding game. The 1886 Browns are in the other side of the bracket, seeded sixth, and are taking on the 1934 Cards. Good luck to the various incarnations of the Four Time Champions.
Looking at the bracket, my final four picks are the 1885 Browns, the 1943 Cards, the 1985 Cards (Go Crazy, Folks!), and the 1886 Champions of the World Browns. While I'd love to see a final between the 1885 and 1886 Browns, I think the more interesting final would be between the 1885 Browns and the 1985 Cards.
If you're looking for a dark horse pick (and do I really need to say that if you're gambling on VEB's All-Time Sim Tournament, seek help immediately), I think both the 13th seeded 1926 Rogers Hornsby/Pete Alexander Cards and the 14th seeded 1964 Ken Boyer/Bob Gibson Cards could both make some noise. Yankee Killers both are they.